Systems response profiles to two Rehmanniae Radix formulae in metabolic syndrome patients

To explore the effects of two Rehmanniae Radix formulae in patients with metabolic syndrome (MetS), a randomized controlled study was conducted. MetS patients were randomly assigned to receive either a classic Rehmanniae Six Formula (R6, or ‘Liu Wei Di Huang Wan’) or a novel multi-herbal Rehmanniae Radix containing formula SUB889 for 8 weeks. Western medicine related clinical parameters, Chinese medicine defined symptoms and syndromes as well as metabolomic profiles were evaluated at different time points.