Exploring the roles of Notch inhibitors and STAT3 inhibitors in the regulation of liver cancer proliferation

We discovered that the inhibition of both the Notch and STAT3 signaling pathways effectively suppressed the proliferation of liver cancer cells, which aligns with the results obtained from co-culturing with human hepatocyte-derived liver progenitor-like cells (HepLPCs). Global expression analysis of RNA sequencing data of expression levels of HepG2 and Hep3B in the presence or absence of hepatocytes derived liver progenitor-like cells (HepLPCs), and the global expression of HepG2 and Hep3B genes after combined inhibition of Notch1 and STAT3.