NOTCH3 promotes vascular smooth muscle cells progression by targeting RANBP1

Vascular smooth muscle cells participate in the formation and development of fibrous cap in the early stage of atherosclerosis,Notch3 plays an important role in maintaining the phenotypic stability of VSMCs.However,the molecular mechanism between Notch3 and VSMCs is not fully understood Comparative gene expression profiling analysis of RNA-sequencing data，9 groups of vascular smooth muscle cells Samples for RNA-Sequencing , 3 groups of si-NOTCH3-1, 3 groups of si-NOTCH3-2 and 3 groups of normal control (NC) data, in which NOTCH3 was knocked down by different siRNAs.