The role of microbiota during leptospira infection

Leptospirosis is a worldwide zoonotic disease caused by Leptospira spp. Although there is no literature on L. interrogans as an intestinal pathogen, intestinal bleeding is a common but neglected symptom in severe leptospirosis. However, the interaction between L. interrogans and the gut microbiota is still elusive. The ain of this study was to investigate the function and regulatory mechanisms of the gut microbiota in host defense against leptospirosis.