Constitutive activation of the WNT signaling effector CTNNB1 (β-catenin) in the Sertoli cells of the Ctnnb1tm1Mmt/+;Amhr2tm3(cre)Bhr/+ mouse model results in progressive germ cell loss and sterility.

Figshare2016-01-18 更新40

Severe impairment of male reproductive organ development in a low SMN expressing mouse model of spinal muscular atrophy. Mus musculus breed:C57BL/6

SMA疾病模型

男性不育机制

Spinal muscular atrophy (SMA) is caused by low levels of survival motor neuron (SMN), a multifunctional protein essential for higher eukaryotes. We utilized a mild SMA model (C/C model) to examine the

NIAID Data Ecosystem20

Expression data from 15-day-old mouse testes

男性不育机制

HSF1诱导细胞凋亡

Activation of the Heat Shock Factor 1 (HSF1) in spermatogenic cells leads to apoptosis and infertility of males. To elucidate a mechanisms of apoptosis induced by HSF1 we generated transgenic mice exp

NIAID Data Ecosystem50

Early and late pollen development

花粉发育基因

男性不育机制

Male sterility line plays an important role in hybrid seed production via exploiting heterosis. The difference expression genes related to pollen development between male sterility and maintain line w

NIAID Data Ecosystem30

Transcriptome and proteome correlation analysis

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