Small non-coding RNA sequencing of MeCP2-deficient cells. Mus musculus

Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutations in the X-linked geneMECP2. However, molecular mechanisms of how MeCP2 deficiency leads to RTT pathogenesis are largely unknown. In this study, we performed the deep RNA sequencing using small non-coding RNA fraction from WT or MeCP2-KO neurons and WT or MeCP2 NSCs to identify microRNA that are regulated by MeCP2.