Single cell evaluation of the developing pancreatic tumor microenvironment and its response to chronic jetlag. Single cell evaluation of the developing pancreatic tumor microenvironment and its response to chronic jetlag

Chronic jetlag is a risk factor for cancer development, we subjected mice that develop pancreatic cancer to normal or chronic jetlag conditions and used scRNAseq to evaluate the developing tumor microenvironment Overall design: 1 pololed Male/Female from 5 and 9 month old KrasG12D Pdx1-Cre pancreata subjected to either normal circadian or chonic jetlag conditions were compared with scRNAseq