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Dual host-pathogen RNA-sequencing of R. canadensis infected Vero cells in response to various compound treatments

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NIAID Data Ecosystem2026-03-14 收录
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The goal of this study is to utilize dual host-pathogen NGS to assess transcriptomic pertubations due to multiple drug compounds, and compare between compounds to identify putative mechanism of action for novel anti-Rickettsial compounds. Overall design: RNA sequencing of Vero cells infected with R. canadensis pRAM18dRGA+ and treated with multiple drug compounds (Doxycycline, Rifampin, Chloramphenicol, Duartin, JSF-3204) to assess comparative transcriptomes

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2023-03-03
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