WP4705 - Pathways of nucleic acid metabolism and innate immune sensing - Homo sapiens
收藏NIAID Data Ecosystem2026-05-02 收录
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资源简介：
Cytosolic DNA and RNA can lead to innate immune sensing via three paths. DNA is sensed by cGAS, which activates STING.
RNA is sensed by MDA5 and RIG-I, which activates MAVS. An activation of STING or MAVS lead to phosphorylation of IFR3, which triggers innate immune responses.
This pathway was inspired by Chapter 14 of the 5th edition of the book of Blau.
创建时间：
2025-04-17
