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Single association results of the present tested 58 MS risl loci.

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Figshare2015-12-03 更新2026-04-29 收录
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58 tested MS-risk loci, ranked by p-value for allele frequency comparison between MS patients and healthy controls. The left column contains the gene name used by IMSGC & WTCCC2, the second column contains the dbSNP rs-number. Column three comprises the one tailed allelic p-values calculated with one degree of freedom (df = 1). Column four represents the identified risk allele. Column five contains the odds ratios (OR) for the corresponding risk alleles. Column six depicts the 95% confidence interval (C.I.) of the corresponding OR. Column seven reflects the MS risk alleles identified and defined by the IMSGC & WTCCC2 study. Column eight shows the consistency between the MS-risk alleles as identified in the present and the IMSGC & WTCCC2 study - x = discrepancy o = consistency;* = markers passing Benjamini and Hochberg correction for multiple testing (pcorr-value ⱡ markers with puncorr-values # = SNPs not passing HWE criteria. Column nine displays the power to replicate previous findings of the IMSGC & WTCCC2 study in our concise cohort for their given ORs and allele frequencies using a recessive model (most conservative) in QUANTO. Underlined corresponds to the identified inconsistency for the previously identified risk alleles with puncorr corr Single association results of the present tested 58 MS risl loci.
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2015-12-03
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