Genomic data for Tracing SARS-CoV-2 clusters across local scales: Greater Houston, January–October 2021

A quantitative understanding of local transmission dynamics is essential for designing effective prevention strategies. In this study, we developed a novel algorithm to identify introductions and trace locally circulating clusters. We analyzed over 26,000 SARS-CoV-2 genomes and their associated metadata, collected between January and October 2021, to explore introduction and dispersal patterns in Greater Houston, a major metropolitan area known for its demographic diversity. Our analysis identified more than 1,000 independent introduction events, resulting in clusters of varying sizes. The majority of introductions originated from domestic sources, while international introductions occurred earlier and were associated with larger cluster sizes. An analysis of locally circulating clusters revealed age-structured transmission dynamics. Geographic reconstruction of cluster spread identified Harris County as the primary viral source for surrounding counties. Harris County sustained the loca..., This dataset includes genomic data and associated demographic metadata used to trace SARS-CoV-2 clusters in Greater Houston from January to October 2021. It provides GISAID accession IDs and demographic metadata, which are available in XML files formatted for BEAST analyses., , # Genomic Data for Tracing SARS-CoV-2 Clusters Across Local Scales: Greater Houston, January–October 2021

[https://doi.org/10.5061/dryad.0000000ds](https://doi.org/10.5061/dryad.0000000ds)

## Description of the data and file structure

Here, we provide GISAID accession IDs and demographic metadata, which are available in XML files formatted for BEAST analyses.
### Files and variables

#### File: texasAndContexual.tsv

**Description:** It provides GISAID accession IDs used in this study. Our dataset comprises 26,138 complete SARS-CoV-2 genomes, including 9,186 sampled from Houston and 16,952 contextual sequences from around the world.

##### Variables

* IDs

#### File: age.xml

**Description:** The XML file for BEAST runs contain the associated age group for the sampled patients in Houston.

#### File: GLMcounty.xml

**Description:** The XML file for BEAST runs contain the associated sampling location (county) for the sampled patients in Houston.

#### File: sex.xml

**Description:** ...,