Text S1 - Modeling of Pharmacokinetics of Cocaine in Human Reveals the Feasibility for Development of Enzyme Therapies for Drugs of Abuse

Supplementary material available including (1) analysis of the structural identifiability of the model; (2) detailed data for the impacts of the catalytic parameters of enzyme on cocaine concentration in brain; (3) additional information about the evaluation of available high-activity cocaine-metabolizing enzymes for their effects on the cocaine concentration in brain. (PDF)