Dose Reduction or Discontinuation of Etanercept in Methotrexate-Treated Rheumatoid Arthritis Subjects Who Have Achieved a Stable Low Disease Activity-state (DOSERA)

This study involves Rheumatoid Arthritis patients in regular clinical setting who are already
on etanercept treatment and are in remission or in a low disease activity (LDA) state, and is
intended to identify parameters that can serve as guidance in clinical settings. This study
will consider the clinical and radiographic course in subjects when etanercept treatment is
tapered or discontinued, and analyze the subjects' experience of disease worsening and the
predictive values of clinical parameters, serum biomarkers and imaging on the clinical and
radiographic course in different treatment groups. The effect of re-treatment with etanercept
at treatment failure will also be studied.