Comparison of acoustic density analysis before and after insonation(–x±s).

Data are the means±standard deviations. MEUS means microbubble-enhanced (therapeutic) ultrasound; TUS means therapeutic ultrasound only without microbubbles; MB means no pulses were transmitted by the transducer only injected microbubbles. *P<0.05 indicates a significant difference between before and after insonation of the MEUS group. +P<0.05 indicates a significant difference between the MEUS group and the controls.