The c-mos gene product is required for cyclin B accumulation during meiosis of mouse eggs.
收藏PubMed Central1991-09-01 更新2026-05-16 收录
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https://pmc.ncbi.nlm.nih.gov/articles/PMC52405/
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资源简介：
The c-mos protooncogene is expressed as a maternal message that is required for oocyte meiosis. The mechanism of action of c-mos was investigated by analysis of mouse eggs injected with antisense c-mos oligonucleotides. In antisense-injected eggs, maturation-promoting factor was not reactivated after the completion of meiosis I, leading to the formation of nuclei containing decondensed chromatin within 2-3 hr after polar body extrusion. This was correlated with a failure of the injected eggs to accumulate newly synthesized cyclin B. The c-mos protooncogene thus appears to affect the pathway that regulates cyclin B stability during meiosis of mouse eggs. IMAGES:
提供机构：
National Academy of Sciences
创建时间：
1991-09-01
