The Role of microRNAs in Neural Stem Cell-supported Endothelial Morphogenesis

MicroRNA microarrays and RNA expression arrays were used to identify functional signaling between neural stem cell progenitor cells (NSPC) and brain endothelial cells (EC) that are critical during embryonic development and tissue repair following brain injury. Mouse neural stem /progenitor cells (NSPC) and brain endothelial cells (EC) were co-cultured to identify changes in gene and miRNA profiles induced in ECs under the influence of NSPCs