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Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss

ChEBI2016-03-14 更新2026-07-12 收录

神经退行性机制

ALS蛋白毒性

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-78730 数据链接链接失效反馈

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Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss

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创建时间：

2016-03-14

神经退行性机制

细胞应激通路

Ribosome stalling during translation has recently been shown to cause neurodegeneration, yet the signaling pathways triggered by stalled elongation complexes are unknown. To investigate these pathw

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AAGGG repeat expansions trigger RFC1-independent synaptic dysregulation in human CANVAS Neurons. AAGGG repeat expansions trigger RFC1-independent synaptic dysregulation in human CANVAS Neurons

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This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

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Additional file 15 of Comparative analysis of transcriptome remodeling in plaque-associated and plaque-distant microglia during amyloid-β pathology progression in mice

神经退行性机制

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Additional file 15: Table S3. Expression values for all expressed genes (in pseudocounts), related to Fig. 2.

Figshare2022-09-26 更新20

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GM2神经节苷脂沉积症模型

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Tay-Sachs and Sandhoff diseases are lethal inborn errors of acid β-N-acetylhexosaminidase activity, characterized by lysosomal storage of GM2 ganglioside and related glycoconjugates in the nervous sys

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Loss of TREM2 reduces hyperactivation of progranulin deficient microglia but not lysosomal pathology [14 months]

神经退行性机制

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GRN haploinsufficiency causes frontotemporal lobar degeneration and results in microglial hyperactivation, lysosomal dysfunction and TDP-43 deposition. To understand the contribution of microglial hyp

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Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss

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