Profiling of expression data in melanoma cells with mutant DOT1L or treated with DOT1L inhibitor
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE103079
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DOT1L-dependent H3K79 methylation is associated with telomere silencing, meiotic checkpoint control, DNA repair, modulation of constitutive heterochromatin, and transcriptional activation. We used microarrays to detail the global program of gene expression in C021 melanoma cells (DOT1L wild type) and C025 melanoma cells (DOT1L mutant) treated with DMSO vehicle control, and in C021 cells treated with the DOT1L inhibitor EPZ-5676.
创建时间:
2021-07-25



