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p38 MAP kinase signaling in microglia plays a sex-specific protective role in CNS autoimmunity and regulates microglial transcriptional states

NIAID Data Ecosystem2026-03-13 收录

胶质细胞转录组学

中枢神经系统自身免疫

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE185045 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

应用场景：

创建时间：

2021-11-04

胶质细胞转录组学

药物神经免疫机制

DNL919 induces durable response in microglia evidenced by mild-to-strong activation of DAM, cell cycle, and immune related pathways at day 7. Overall design: TB36; hTfR KI mice were administrated with

NIAID Data Ecosystem110

RNA-seq of microglia from 3-dpf siblings, mafba and mafbb single mutant and DMut zebrafish

斑马鱼基因功能

胶质细胞转录组学

In order to search for the downstream target genes of Mafba and Mafbb, we isolated microglia (3 cells per sample) from 3-dpf zebrafish brain of siblings, mafba and mafbb single mutants and DMut under

NIAID Data Ecosystem70

Defining the microglial transcriptome in the rat subventricular zone (SVZ) after neonatal hypoxia-ischemia (HI).. Rattus norvegicus

新生儿缺氧缺血性脑病

胶质细胞转录组学

Purpose: Recent findings indicate a regulatory role of microglia on neurogenesis in the SVZ in health and disease. Microglia in the early postnatal SVZ are not fully maturated and may react differentl

NIAID Data Ecosystem50

Additional file 2 of Microglial transcriptome analysis in the rNLS8 mouse model of TDP-43 proteinopathy reveals discrete expression profiles associated with neurodegenerative progression and recovery

TDP43蛋白病

胶质细胞转录组学

Additional file 2. Comparison of principal component scores between male and female rNLS8 control mice.

Figshare2024-02-20 更新80

Next generation sequencing revealed disease-specific microglia classes relying on distinct transcriptomes. Next generation sequencing revealed disease-specific microglia classes relying on distinct transcriptomes

神经病理机制

胶质细胞转录组学

Microglia in the spinal dorsal horn have been implicated in the pathogenesis of neuropathic pain following peripheral nerve injury. We have revently found that CD11c-expressing spinal microglia appear

NIAID Data Ecosystem70

p38 MAP kinase signaling in microglia plays a sex-specific protective role in CNS autoimmunity and regulates microglial transcriptional states

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