Base-Mediated Hydroamination of Propargylamine: A Regioselective Intramolecular 5-exo-dig Cycloisomerization en Route to Imidazole-2-thione
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https://figshare.com/articles/dataset/Base_Mediated_Hydroamination_of_Propargylamine_A_Regioselective_Intramolecular_5_i_exo_dig_i_Cycloisomerization_en_Route_to_Imidazole_2_thione/2238178
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An intramolecular transition-metal-free base-mediated hydroamination of propargylamine with isothiocyanates has been achieved. This atom-economical, regioselective intramolecular 5-exo-dig cycloisomerization was utilized for the one-pot synthesis of diversely substituted imidazole-2-thione and spiro-cyclic imidazolidine-2-thione. The reaction goes to completion at room temperature via propargylthiourea and 65–97% isolated yields were obtained.
创建时间：
2016-02-16
