Tumor-resident T-cell regulate responses to checkpoint blockade immunotherapies
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In cancer models, CD103+CD8 TRM cells are implicated in the response to anti-PD-1 immunotherapy, and a subset of CD4 TRM cells expressing the integrin CD49a is required for response to anti-CTLA-4 immunotherapy. We performed single-cell RNA sequencing on tumour-infiltrating T lymphocytes (TILs) isolated from colon carcinoma et unsupervised analyses reveal several TRM populations. Dataset contains the CD4+CD8+ combined Seurat object and the corresponding TCR sequencing data.
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Zenodo创建时间：
2025-04-28
