Transcriptomic signature of spinal cord from CHMP2Bintron5 mice

We report transcriptomic dysregulations in the spinal cord of asymptomatic (A: 1.5 months) symptomatic (S: 6 months) and end stage (E: 10-12 months) CHMP2Bintron5 mice by RNA sequencing. We found that genes related to immune system and lipid metabolism had altered expression levels at 1.5 month. Expression of genes related to neuronal system was atletred at 6months and expression of genes related to neuronal system and extracellular matrix xere dfound deregulated at the end-stage. These results were used to determine the change of transcriptomic profile throughout the course of the disease. Overall design: At 1.5 month: 4 spinal cord samples from CHMP2Bintron5 mice and 6 spinal cord samples of non-transgenic control mice were analyzed. At 6 months: 4 spinal cord samples from CHMP2Bintron5 mice and 5 spinal cord samples of non-transgenic control mice were analyzed. At 12 months: 6 spinal cord samples from CHMP2Bintron5 mice and 6 spinal cord samples of non-transgenic control mice were analyzed.