RNA sequencing of posterior fossa ependymoma harboring 6q loss

Two distinct groups of posterior fossa ependymoma, PF-EPN-A and PF-EPN-B have been identified in children and are often associated with widely distinct outcomes. We have identified an ultra-high-risk PF-EPN-A ependymoma with 6q loss. We performed RNA sequencing of posterior fossa ependymoma A (PF-EPN-A) tumor samples with chromosome 6q loss and balanced to understand the differences in 6q loss at the transcriptomic level Overall design: Transcriptomic profiles of 10 ependymoma samples with chromosome 6q loss and balanced 6q status with 5 samples in each category