WP5199 - PtdIns(4,5)P2 in cytokinesis pathway - Homo sapiens

Phosphatidylinositol 4,5-bisphosphate -- also known as PtdIns(4,5)P2 or PIP2 or PI(4,5)P2 -- acts as a central component in the process of bridge stability during the final steps of cytokinesis. Furthermore, PtdIns(4,5)P2 shows bidirectional interactions with many different metabolites such as anillin, ERM-complex. But also Septin2, F-actin and other depicted components visualized in the pathway are required to finalize cytokinesis between two sister cells.