Unconscious emotional conflict in major depressive disorder: A simultaneous EEG-fMRI study

According to the cognitive model of depression, biased acquisition and evaluation of emotional infor-mation are the key elements for developing and maintaining depression (Beck, 1987). Maladaptive functions in depression are primarily explained by two mechanisms; i) hyperactive responses to nega-tive information initiate an emotional processing bias, even when the negative information has been unconsciously perceived, and ii) attenuated cognitive control impairs evaluation of the biased infor-mation (for an overview, see Disner et al., 2011). The present project aims to construct an empirical neural model that provides separate mechanisms in clinical depression by which i) emotion processing is biased at an unconscious level and ii) the resulting effects of unconscious processing are controlled on a conscious level.-masked emotional conflict task to a large sample of participants. A multimodal neuroimaging technique with EEG and fMRI is applied.

Licence: CC-By Attribution 4.0 International

根据抑郁症的认知模型，对情绪信息的偏差性获取与评估是抑郁症发作与维持的核心要素（Beck，1987）。抑郁症的适应不良功能主要可通过两种机制阐释：其一为对负性信息的过度激活反应，即便负性信息处于无意识感知状态，也会诱发情绪加工偏差；其二为认知控制能力减弱，损害了对偏差信息的评估过程（综述详见Disner等，2011）。
本项目旨在构建一项实证神经模型，以分别阐明临床抑郁症中的两类机制：一是情绪加工在无意识层面发生偏差，二是无意识加工产生的效应可在意识层面受到调控。本研究采用掩蔽情绪冲突任务对大样本参与者开展测试，并应用脑电图（Electroencephalogram, EEG）与功能磁共振成像（functional Magnetic Resonance Imaging, fMRI）的多模态神经影像技术。

许可证：知识共享署名4.0国际许可（CC-BY Attribution 4.0 International）

搜集汇总

背景与挑战

背景概述

该数据集专注于研究重度抑郁症（MDD）患者与健康对照组在无意识情绪冲突中的神经机制，采用后向掩蔽启动范式和同步EEG-fMRI技术来探索情绪处理偏见和认知控制。数据集包含140名参与者（70名MDD患者和70名健康对照），通过操作启动刺激的时机和情绪，测量脑血流动力学反应、神经电活动及行为数据，旨在构建抑郁症的神经模型并分析无意识情绪冲突的效应。