Efficacy and Safety of JAK-Inhibitors in Treating Refractory Palmoplantar Pustulosis and Palmoplantar Pustular Psoriasis: A Systematic Review

Palmoplantar pustulosis (PPP) and palmoplantar pustular psoriasis (PPPP) are rare, chronic inflammatory skin diseases affecting the palms and soles. Conventional treatment approaches include topical, systemic and biological therapy in severe and refractory cases, although neither are curative. This systematic review identifies and summarizes response to Janus Kinase inhibitors (JAKi) therapy in patients with PPP and PPPP refractory to conventional treatment.