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Cu(II)-Catalyzed Coupling of Aromatic C–H Bonds with Malonates

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NIAID Data Ecosystem2026-03-08 收录
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https://figshare.com/articles/dataset/Cu_II_Catalyzed_Coupling_of_Aromatic_C_H_Bonds_with_Malonates/2189512
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A new Cu­(II)-catalyzed oxidative coupling of arenes with malonates has been developed using an amide-oxazoline directing group. The reaction proceeds via C­(sp2)–H activation and malonate coupling, followed by intramolecular oxidative N–C bond formation. A variety of arenes bearing different substituents are shown to be compatible with this reaction.
创建时间:
2016-02-14
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