Voxel-Based Contrast for the Whole Cohort (22 MDD Versus 22 Matched Controls).

Positive t values indicate FA values were elevated in MDD subjects relative to control subjects; negative t values indicate FA values were reduced in MDD subjects relative to control subjects. p values are reported uncorrected; symbols indicate significance and trends at the corrected threshold. *p value met the corrected threshold. †p value was within an order of magnitude of the corrected threshold (a trend). Abbreviations: R: right hemisphere; L: left hemisphere; wm: white matter; gm: gray matter; VTA/SN: ventral tegmental area/substantia nigra; MFB: medial forebrain bundle; LNH: lateral nucleus of the hypothalamus; ACC anterior cingulate cortex; DLPFC: dorsolateral prefrontal cortex; PAC: paracingulate cortex; PMC: premotor cortex; CC: corpus callosum; CCtx: calcarine cortex.