Hyaluronan (HA) is a naturally occurring glycosaminoglycan polymer produced in all vertebrates, and usually present at high molecular weight (>106Da). Low molecular weight HA has signaling properties, and fragments ~35kDa size (HA35) have biological activity in eliciting epithelial -defensins and tight junction proteins, notably ZO1, important components of innate host defense arsenal of the gut barrier. Despite efficacy of HA35 in preclinical models, the safety of oral HA35 in humans is currently unknown.. HA35

Hyaluronan (HA) is a naturally occurring glycosaminoglycan polymer produced in all vertebrates, and usually present at high molecular weight (>106Da). Low molecular weight HA has signaling properties, and fragments ~35kDa size (HA35) have biological activity in eliciting epithelial -defensins and tight junction proteins, notably ZO1, important components of innate host defense arsenal of the gut barrier. Despite efficacy of HA35 in preclinical models, the safety of oral HA35 in humans is currently unknown.