Data of study "Lateral septum neurons that disable sociability in an autism mouse model

Data of study  "Lateral septum neurons that disable sociability in an autism mouse model"

Authors: Borie and colleagues

contact information

[e-mail]

Orcid 0000-0002-9606-2892

institut de genomique fonctionnelle

141 rue de la Cardonille 

34090 Montpellier

France

Description of data presented by main figures

***Calcium activity in SST neurons of LS during social behavor Figure 1D***

data of photometry

***Area under spikes of knockout model Figure 1E***

data of in vivo photometry

***Spike duration of knockout model Figure 1F***

data of in vivo photometry

***Proportion of SST neurons in LS expressing c-FOS in Magel2 KO mice Figure 1G***

data of histology

***Optogenetic inhibition of SST neurons in LS of knockout model restored social discrimination Figure 1I***

data of mouse behavior

*** Injection of SSTR antagonist in LS of knockout model restored social discrimination Figure 1K***

data of mouse behavior

***Injection of SST in LS of WT mice restored social discrimination Figure 1L***

data of mouse behavior

***Proportion of SST neurons in LS expressing OXTR in Magel2 KO mice Figure 2B***

data of histology

***Density of SST neurons in LS of Magel2 KO mice Figure 2C***

data of histology

***Frequency of action potential in LS neurons inhibited by AVP then TGOT in WT mice Figure 2E***

data of electrophysiology ex vivo

***Frequency of action potential in LS neurons inhibited by AVP and TGOT in Magel2KO mice Figure 2F***

data of electrophysiology ex vivo

***Proportion of SST neurons insensitive to AVP and TGOT Figure 2G***

data of histology

***Frequency of action potential in LS neurons inhibited by AVP with GABAzine  Figure 2J***

data of electrophysiology ex vivo

***Frequency of action potential in LS neurons inhibited by TGOT  with GABAzine Figure 2K***

data of electrophysiology ex vivo

***Pharmacological inhibition of AVPR and OXTR during social novelty in Magel2 WT mice Figure 3A***

data of mouse behavior

***Effect of inhibitors injected during social novelty on the proportion of SST neurons with cFOS after social discrimination Figure 3C***

data of histology

***Pharmacological inhibition of AVPR and OXTR during social habituation in Magel2 WT mice Figure 3D***

data of mouse behavior

***Effect of inhibitors injected during social habituation on the proportion of SST neurons with cFOS after social discrimination Figure 3F***

data of histology

***Co-injection of AVP with antagonist of AVPR and OXTR in Magel2 KO mice Figure 3G***

data of mouse behavior

***Area under spikes in OXT neurons of PVN of WT mice Figure 4C***

data of in vivo photometry

***Proportion of OXT neurons in PVN expressing c-FOS in Magel2 KO mice Figure 4E***

data of histology

***Area under spikes in AVP neurons of PVN of WT mice Figure 4H***

data of in vivo photometry

***Proportion of AVP neurons in PVN expressing c-FOS in Magel2 KO mice Figure 4J***

data of histology

***Optogenetic inhibition of oxytocinergic or vasopressinergic PVN-LS pathways in Avp-CRE or OXT-Cre mice Figure 5B***

data of mouse behavior

***Optogenetic inhibition of oxytocinergic or vasopressinergic SON-LS pathways in Avp-CRE or OXT-Cre mice Figure 5D***

data of mouse behavior

***Optogenetic activation of oxytocinergic or vasopressinergic PVN-LS pathways in Magel2 KO;Avp-CRE or Magel2 KO;OXT-Cre double transgenic mice Figure 5F***

data of mouse behavior

***Optogenetic activation of oxytocinergic or vasopressinergic SON-LS pathways in Magel2 KO;Avp-CRE or Magel2 KO;OXT-Cre double transgenic mice Figure 5H***

data of mouse behavior