Is This Staphylococcal Prosthetic Joint Infection Mono- or Polymicrobial? A Case Report

In current diagnostic criteria for implant-associated bone- and joint infections, phenotypically identical low-virulence bacteria in two intraoperative cultures are usually required. Using whole-genome sequencing, we have further characterized three phenotypically different Staphylococcus capitis isolated from one prosthetic joint infection, highlighting the challenges in defining criteria for low-virulence prosthetic joint infections.