Etrolizumab-s fails to control E-Cadherin-dependent co-stimulation of highly stimulated cytotoxic T cells associated with Crohn’s disease

To interrogate the potential of αEβ7 integrin as a target in Crohn’s disease (CD), we single cell RNA-sequenced T cells from a patient with CD and a non-IBD control We sorted integrin α4-expressing memory T cells from the peripheral blood of a control donor and patient with CD and submitted these cells to single cell RNA-sequencing