Non-breast/ovarian tumors in germline BRCA1/2 carriers
收藏NIAID Data Ecosystem2026-05-01 收录
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资源简介：
Breast and ovarian tumors in germline BRCA1/2 carriers undergo allele-specific loss of heterozygosity, resulting in homologous recombination deficiency (HRD) and sensitivity to poly-ADP-ribose polymerase (PARP) inhibitors. This study investigated whether biallelic loss and HRD also occur in primary nonbreast/ovarian tumors that arise in germline BRCA1/2 carriers.
创建时间：
2023-10-25
