Ni(II) Tol-BINAP-Catalyzed Enantioselective Orthoester Alkylations of <i>N</i>-Acylthiazolidinethiones
收藏NIAID Data Ecosystem2026-03-06 收录
数据链接：
官方服务：
资源简介：
The development of a Ni(II) (S)-Tol-BINAP-catalyzed enantioselective alkylation of N-acylthiazolidinethiones with trimethyl orthoformate is described. The reaction is general with respect to the thiazolidinethione, providing the desired adducts in good to excellent yield and with high levels of enantioselectivity (11 examples, 51−92% yield, 90−99% ee). The products are readily converted into a variety of synthetically useful derivatives in a straightforward manner.
创建时间：
2005-08-03
