Different types of pesticide exposure and lung cancer incidence in the Agricultural Health Study cohort: A systematic review and meta-analysis

Lung cancer is the dominant cause of worldwide cancer mortality. The relationship between pesticide exposure and lung cancer risk has shown mixed results epidemiologically. We hypothesized this discrepancy could arise from the varying effects of different pesticides and conducted this meta-analysis by using three pesticide classification schemes to examine the implications of diverse pesticide exposure types on lung cancer risk. We collected 23 studies to assess the risk of lung cancer with pesticide exposure in the Agricultural Health Study cohort (AHS), and our analysis indicated a surplus incidence of lung cancer associated with organochlorine pesticides (OR = 1.35, 95% CI = 1.04-1.74). However, no significant association was found between exposure to a general set of 33 pesticides and lung cancer risk (OR = 1.04, 95% CI = 0.96-1.13). We anticipate these findings will influence future pesticide application, promoting improved occupational health.