Efficacy of a single injection of entolimod in increasing 40-day survival of lethally irradiated NHPs when administered at different dose levels within 1–48 hours after TBI.

A P-value by Fisher's exact test (two-tailed) for comparisons vs. vehicle groups within individual studies or in pooled group analysisB P-value by Log rank test (two-tailed) for comparisons vs. vehicle groups within individual studies or in pooled group analysisC Source I: Sichuan Atomic Energy Institute, cylindrical bundle of Co-60 rodsD Source II: Sichuan Atomic Energy Institute, vertical array of Co-60 rodsE Vehicle-treated animals from studies Rs-03, Rs-06, Rs-09, and Rs-14F Entolimod-treated animals from studies Rs-06 and Rs-14G Survival odds and survival odds ratios adjusted due to 100% survival are shown in italicsNote: The frequency of moribund euthanasia was as follows: Study Rs-03–91% (1/11—found dead), Study Rs-06–100%; Study Rs-09–85% (3/20 –found dead); Rs-14–88% (1/8 –found dead). The likely cause of death in all the non-euthanized animals was acute hemorrhage.Efficacy of a single injection of entolimod in increasing 40-day survival of lethally irradiated NHPs when administered at different dose levels within 1–48 hours after TBI.