IgE_GXB_Database

Here, we present a curated collection of transcriptomic datasets relevant to immunoglobin E (IgE)-mediated atopic diseases (ranging from allergies to primary immunodeficiencies). 30 datasets from the Gene Expression Omnibus, encompassing 1761 transcriptome profiles, were made available on the Gene Expression Browser (GXB), an open-source web application that allows for the query, visualization, and annotation of metadata. The thematic compositions, disease categories, sample number, and platforms of the collection are described. Ranked gene lists and sample grouping are used to facilitate data visualization/interpretation and are available online via GXB (http://ige.gxbsidra.org/dm3/geneBrowser/list). Dataset validation using associated publications showed good concordance in gene expression trend and fold-change.