Tumor heterogeneity and lack of knowledge about resistant cell states remain a significant barrier to effective targeted cancer therapies. Basal cell carcinomas (BCCs) uniformly depend on Hedgehog (Hh
The identification of the potential mechanisms of resistance while tumor cells still respond to therapy is critical to develop combination therapies to delay acquired resistance. Cetuximab, an anti-EG
The plasticity and heterogeneity of cancer cells are known to play a major role in malignant progression, yet the precise molecular drivers of metastases remain elusive. We performed single-cell RNA-S