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Common Deleterious Germline Variants Shape the Urothelial Cancer Genome

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NIAID Data Ecosystem2026-04-30 收录
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https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001087.v4.p1
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Our study used whole-exome, whole-genome, and RNA sequencing to analyze samples from primary tumors, locally recurrent or metastatic urothelial tumors collected over time, and matched normal urothelium. We described the molecular landscape of mutational signatures and structural variants in chemotherapy-resistant urothelial cancer.]]> Inclusion Criteria:Patients with advanced urothelial carcinomaPatients with bladder cancer Patients with upper tract urothelial carcinoma Exclusion Criteria:Patients with low-grade tumors ]]>
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2022-02-28
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