X-ray crystal structure of darunavir-resistant HIV-1 protease (P30) in complex with GRL-001
收藏Protein Data Bank Japan2023-10-11 更新2026-03-21 收录
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X-ray crystal structure of darunavir-resistant HIV-1 protease (P30) in complex with GRL-001 Descriptor: (3S,3aR,5R,7aS,8S)-hexahydro-4H-3,5-methanofuro[2,3-b]pyran-8-yl [(2S,3R)-4-[{[2-(cyclopropylamino)-1,3-benzothiazol-6-yl]sulfonyl}(2-methylpropyl)amino]-1-(3-fluorophenyl)-3-hydroxybutan-2-yl]carbamate, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... Authors: Bulut, H, Hattori, S.I, Aoki-Ogata, H, Hayashi, H, Aoki, M, Ghosh, A.K, Mitsuya, H. Deposit date: 2019-04-03 Release date: 2020-04-08 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.27 Å) Cite: Single atom changes in newly synthesized HIV protease inhibitors reveal structural basis for extreme affinity, high genetic barrier, and adaptation to the HIV protease plasticity. Sci Rep, 10, 2020
创建时间：
2019-04-03
