The Heterochromatin protein 1 is a regulator in RNA splicing precision deficient in ulcerative colitis

NIAID Data Ecosystem2026-03-14 收录

RNA剪接调控

溃疡性结肠炎

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https://www.ncbi.nlm.nih.gov/sra/SRP352942 数据链接链接失效反馈

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Total RNA was extracted from mouse Villin-creERT2:Cbx3-/- mice epithelial cells from the small intestine crypt, villi and colon epithelia Overall design: 18 samples

创建时间：

2022-11-24

Regulation of constitutive and alternative messenger RNA splicing across the human transcriptome by PRPF8 is determined by 5' splice site strength. Regulation of constitutive and alternative messenger RNA splicing across the human transcriptome by PRPF8 is determined by 5' splice site strength

RNA剪接调控

转录组学

RNA-sequencing experiments performed on control siRNA treated and PRPF8 depleted cells

NIAID Data Ecosystem80

The impact of Prp18p on splicing fidelity and efficiency in budding yeast

剪接保真度

RNA剪接调控

Fidelity of 3´-splice site (3´SS) selection by the spliceosome is critical for proper gene expression but is a daunting task considering the low complexity of the 3´SS consensus YAG. Here we show that

Alliance of Genome Resources40

An uncharacterized gene, C7orf26, identified from an autosomal dominant ocular disease functions in mRNA splicing. An uncharacterized gene, C7orf26, identified from an autosomal dominant ocular disease functions in mRNA splicing

RNA剪接调控

常染色体显性眼病

An uncharacterized gene, C7orf26 was expected to function with the integrator complex in mRNA splicing. To address the involvement of mRNA splicing, we performed microarray analysis of HeLa/C7orf26 si

NIAID Data Ecosystem30

C9ORF72 GGGGCC expanded repeats produce splicing dysregulation which correlates with disease severity in amyotrophic lateral sclerosis [HuEx-1_0-st]

神经退行性分子机制

RNA剪接调控

Objective: An intronic GGGGCC-repeat expansion of C9ORF72 is the most common genetic variant of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. The mechanism of neurodegeneration is u

NIAID Data Ecosystem50

Integrative genome-wide analysis reveals cooperative regulation of alternative splicing by hnRNP proteins (RNA-Seq)

RNA剪接调控

hnRNP蛋白功能

Understanding how RNA binding proteins control the splicing code is fundamental to human biology and disease. Here we present a comprehensive study to elucidate how heterogeneous nuclear ribonucleopar

NIAID Data Ecosystem40

The Heterochromatin protein 1 is a regulator in RNA splicing precision deficient in ulcerative colitis

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