Consequences of collagen induced inflammatory arthritis on circadian regulation of the gut microbiome.

Autoimmune diseases, such as rheumatoid arthritis, are associated with significant gut microbiota dysbiosis. Here we show that remodelling of 24h rhythms within the gut during inflammatory joint disease drives profound changes in the microbiome and gut permeability. RNA-Seq from mRNA of mouse colon across the course of a day. Time-series include mRNA profiles from DBA/1 mice with collagen-induced arthritis (CIA) on day 7 after the development of disease symptoms and also at matched time points in naïve control mice.