Activation of b-CATENIN in Fibro/Adipogenic Progenitors Leads to Muscle Mass Loss

We induced b-CATENIN transcriptional activity in MPs via inducible deletion of its ubiquitination site. As a result, we observed expansion of MPs in the absence of tissue damage, as well as rapid loss of muscle mass. Overall design: To assess the role of b-CATENIN in mesenchymal progenitors (MPs), tamoxifen was injected in Hic1CREERT2 :b-CATENIN exon3 WTflox mice:Td.tomato mice. Tomato+ cells from skeletal muscle were sorted and subjected to RNA sequencing