NAT10 is identified as a novel driver for brain metastasis

Metastatic breast cancer remains a major cause of cancer related deaths in women and there are few effective therapies against this advanced disease. Using in vivo and in vitro genetic screens, we identified NAT10 as a driver for breast cancer brain metastassis. Here, we profile the transcriptome of metastatic breast cancer cells MDA-MB-231-BrM3 following NAT10 knockdown, aiming to identify the downstream effectors of NAT10. RNA-seq analyses in human breast cancer cell line MDA-MB-231-BrM3 with shCtrl or shNAT10.