<strong>Self-powered enzyme-linked microneedle patch for scar-prevention healing of diabetic wounds-</strong>original data file.xlsx

Diabetic wounds with complex pathological features and difficult-to-heal nature remain a formidable challenge. To address this challenge, we design and fabricate a self-powered enzyme-linked microneedle (MN) patch composed of anode and cathode MN arrays, which respectively contain glucose oxidase (GOx) and horseradish peroxidase (HRP) encapsulated in ZIF-8 nanoparticles. The enzymatic cascade reaction in the MN patch can effectively reduce local hyperglycemia in diabetic wounds while generating stable microcurrents to promote rapid healing of diabetic wounds. Therefore, the diabetic wounds treated with this MN patch exhibit rapid, complete, and scar-prevention healing, which can be attributed to the synergistic actions of hypoglycemic, antibacterial, anti-inflammatory, and bioelectrical stimulation. In brief, the self-powered MN patch is an effective method to rapidly promote diabetic wound healing and prevent scar formation. <strong>Fig. 3.</strong> <strong>Antibacterial test of the synthesized materials. </strong> <strong>Fig. 4.</strong> <strong>Biocompatibility of the MN patches. </strong> <strong>Fig. 5 The healing effect evaluation of the diabetic wound. </strong> <strong>Fig.</strong> <strong>7.</strong> <strong>Evaluation for</strong> <strong>inflammatory factors on the 21st day. </strong> <strong>Fig. 8.</strong> <strong>Evaluation for CD31, CD34, and MMP9. Fig.</strong> <strong>S2.</strong> <strong>Characterization of the synthesized materials.</strong> <strong>Fig.</strong> <strong>S4.</strong> <strong>Current output of the ZGH-MN. </strong> <strong>Fig.</strong> <strong>S5.</strong> <strong>Mechanical strength of the MN patches.</strong> <strong>Fig.</strong> <strong>S5.</strong> <strong>Mechanical strength of the MN patches.</strong> <strong>Fig.</strong> <strong>S7.</strong> <strong>Evaluation for Collagen I and Collagen III. </strong> <strong>Fig.</strong> <strong>S8.</strong> <strong>Evaluation for wound inflammatory factors on the 7th day. </strong> <strong>Fig.</strong> <strong>S9.</strong> <strong>Evaluation for anti-inflammatory factors.</strong>