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Unconventionally-acting PROTACs promote mitochondria health by enhancing ubiquitination-dependent mitophagy

NIAID Data Ecosystem2026-05-02 收录

靶向蛋白降解

细胞自噬调控

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https://data.mendeley.com/datasets/jhpp6dfbyd 数据链接链接失效反馈

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Original data of this manuscript

应用场景：

创建时间：

2025-07-03

靶向蛋白降解

PROTAC

Proteolysis-targeting chimeras (PROTACs), heterobifunctional compounds that consist of protein-targeting ligands linked to an E3 ligase recruiter, have arisen as a powerful therapeutic modality for ta

NIAID Data Ecosystem100

Discovery of LL-K8-22: A Selective, Durable, and Small-Molecule Degrader of the CDK8-Cyclin C Complex

靶向蛋白降解

CDK8-cyclinC抗肿瘤靶点

The CDK8–cyclin C complex is an important anti-tumor target, but unlike CDK8, cyclin C remains undruggable. Modulators regulating cyclin C activity directly are still under development. Here, a series

Figshare2023-03-17 更新30

Protacs: Chimeric molecules that target proteins to the Skp1–Cullin–F box complex for ubiquitination and degradation

靶向蛋白降解

泛素-蛋白酶体系统

The intracellular levels of many proteins are regulated by ubiquitin-dependent proteolysis. One of the best-characterized enzymes that catalyzes the attachment of ubiquitin to proteins is a ubiquitin

PubMed Central2001-07-03 更新20

Cryo-EM structure of the SEA complex wing (SEACIT)

冷冻电镜结构解析

细胞自噬调控

Cryo-EM structure of the SEA complex wing (SEACIT)

NIAID Data Ecosystem40

Bicarbonate Increases Ischemia-Reperfusion Damage by Inhibiting Mitophagy

缺血再灌注损伤

细胞自噬调控

During an ischemic event, bicarbonate and CO2 concentration increase as a consequence of O2 consumption and lack of blood flow. This event is important as bicarbonate/CO2 is determinant for several re

NIAID Data Ecosystem20

Unconventionally-acting PROTACs promote mitochondria health by enhancing ubiquitination-dependent mitophagy

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