Transcriptome analysis of cardiac organoids derived from Duchenne Muscular Dystrophy patient-derived inudced pluripotent stem cells

Duchenne muscular dystrophy (DMD) is a rare genetic disease that leads to progressive muscle weekness and loss of mobility. Dilated cardiomyopathy is the major cause of death however the pathogenesis remains unclear. This is partly due to the limited accessiblity to human samples, the intrinsic limitations of 2D cell cultures and animal models that do not fully recapitulate human disease phenotypes. We aim at developing patient-derived human 3D cardiac models with DMD-relevances to aid disease modeling, drug discovery and regenerative medicine. Bulk RNAseq of cardiac organoids derived from DMD-hiPSC and its isogenic-corrected control lines via CRISPR/Cas genome editing. (n = 3)