Association results of GWA and joint analysis of GWA and replication.

RLS-associated SNPs with genome-wide significance. PGWA, λ-corrected nominal P-value of GWA stage. PREPLICATION, nominal P-value obtained from meta-analysis of the replication stage samples. PJOINT, nominal P-value of the joint meta-analysis of GWA and replication stage, λ-corrected in samples where λ-values were available. Nominal P-values in GWA were calculated using logistic regression with sex, age, and the first four components from the MDS analysis of the IBS matrix as covariates. For nominal PREPLICATION and PJOINT -values, a fixed-effects inverse-variance meta-analysis was performed. Risk allele frequencies and odds ratios were calculated in the joint sample. LD blocks were defined by D' using Haploview 4.2 based on HapMap CEU population data from HapMap release #27. CI, 95% confidence interval. Genome positions refer to the Human March 2006 (hg18) assembly.