Pharmacological properties of TPαR inhibitors and TPαR agonist in R-SAT.

NIH3T3 cells transiently transfected with human AT1R in combination with TPαR, the TPαR R130V, or empty vector and stimulated with AngII alone or in presence of TPαR inhibitors SQ29548, Naproxen, or Flurbiprofen. Also, TPαR in combination with either AT1R or empty vector stimulated with U46619, and the mutant TPαR130V in combination with AT1R or empty vector stimulated with U46619 are shown. The R-SAT analysis was performed as described in the materials and methods section. Data represent the mean ± S.D of 4 independent experiments each performed in duplicate.