Hepatocellular Carcinoma TCGA_LIHC Mutation Information CSV (TCGA_LIHC_Mutation_Input.csv)

Background: While the acquired risk factors of liver cancer in Asia are relatively well understood, the underlying genetic background of liver cancer in Asians has not been well established or correlated with clinical outcomes. Objective: To identify gene mutations linked with worse outcomes in Asian patients with hepatocellular carcinoma (HCC). Methods: A total of 347 Asian and Non-Asian patients with HCC were analyzed in this study. TCGA patient mutation and clinical data were downloaded through TCGAbiolinksGUI and analyzed using the Python NumPy, Matplotlib, seaborn, and SciPy libraries. Statistical significance was determined by Welch’s t-test (unequal variances t-test), with P-values &lt; 0.05 considered to be statistically significant. Results: Mutations in five genes (TP53, TTN, OBSCN, MUC5B, CSMD1) were statistically linked with increased mortality in Asians compared to non-Asians, four of which (TTN, OBSCN, MUC5B, CSMD1) were also more prevalent in the Asian population. Within the Asian cohort, two gene mutations (TTN, HMCN1) were statistically linked with worse outcomes. The TP53 mutation predicts worse outcomes within the non-Asian cohort, but not within the Asian cohort. <b><i>Conclusions:</i></b> This study identified multiple genetic biomarkers that can aid in the recognition, surveillance, prognosis, and gene therapy of HCC.